The University of Puerto Rico, Mayagüez Campus (UPRM) or Recinto Universitario de Mayagüez (RUM) in Spanish, is a land-grant, sea-grant, space-grant state university located in the city of Mayagüez, Puerto Rico. UPRM is the second-largest university campus of the University of Puerto Rico system.

UPRM has been accredited by the Middle States Commission on Higher Education (MSCHE) since 1946. Also, the engineering undergraduate program is accredited by the Accreditation Board for Engineering and Technology (ABET), the nursing undergraduate program is accredited by the National League for Nursing (NLN) and the Chemistry Department is recognized by the American Chemical Society (ACS). The College of Business Administration is going through the process of the AACSB accreditation. The Mayagüez campus of the University of Puerto Rico has been a member of Oak Ridge Associated Universities (ORAU) since 1966.